As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA. A study led by St. Jude Children's Research Hospital recently identified ...
Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin ...
"We found the SWI/SNF variants each serve a unique, important purpose in reorganizing chromatin across the genome and enabling macrophage inflammatory responses," says first author Jingwen Liao, a ...
Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein ...
Most lung adenocarcinoma tumors with EGFR mutations respond to tyrosine kinase inhibitors (TKIs, e.g., osimertinib). Accordingly, there are now >50 different FDA-approved TKIs. Still, acquired ...
In eukaryotic cells, nucleosomes—composed of histone octamers—address the topological challenge of DNA packaging by condensing the DNA within the nucleus., crucial for genetic information storage and ...
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